Ana de Velasco y Téllez-Girón, Duchess consort of Bragança (12 March 1585, Naples – 7 November 1607, Vila Viçosa, Portugal), Spanish noblewoman and mother of João IV of Portugal, the first Portuguese king of the Braganza Dynasty.
She was the eldest daughter of Juan Fernández de Velasco y Tovar, 5th Duke of Frías, and his cousin and first wife María Tellez-Girón y Guzmán, the daughter of Pedro Téllez-Girón y de la Cueva, 1st Duke of Osuna. She was born in Naples, as her parents had accompanied her mother's father, the Duke of Osuna, when he'd been appointed Viceroy of Naples three years earlier.
At the age of eighteen she married Teodósio II, Duke of Braganza; he was thirty-five. She gave birth to four children in four years, three of whom - including the future King João IV - lived to adulthood. But she died after giving birth to the fourth at the age of only twenty-two.